Guggul, Commiphora mukul Review

Commiphora mukul
Abigail Neal
American College of Healthcare Sciences













Guggul or guggulu is considered to have anti-inflammatory, hypoglycemic, antiseptic, thyroid stimulant, anthelminitic, vulnerary, antidiabetic, and hyperlipidemic properties, and many more (Ramesh & Saralakumari, 2012). Science explores guggul for cancer and continues to verify gugguls' use in diabetes.
Constituents guggulsterone and gugulipid have shown to interrupt the signaling pathway of b-catenin (Jiang et al., 2013). B-catenin signaling pathway was downregulated inducing apoptosis cell death of human breast cancer cells and growth was inhibited (Jiang et al., 2013). The gugulipids showed potent inhibiting of breast cancer cell growth. Similarly, in men, guggulu Commiphora mukul is antiproliferative against four human cancer cell lines in prostate cancer (Shen et al., 2016). Isolated compounds from guggulu's resin were antiproliferative- arresting cell cycle in prostate cancer (Shen et al., 2016). Gugulipids in Commiphora mukul resin inhibits cancer cell growth in skin, lung, and colon cancers and leukemia (Xiao & Xiao, 2012). For those individual who choose chemotherapy, gugulipids anticancer property also is a potent chemo-protective (Xiao & Xiao, 2012).
For cases of diabetes, Commiphora mukul lowers serum glucose levels, triglyceride LDL & HDL (Shirazi et al., 2015). Guggulsterones inhibits the synthesis of cholesterol in the liver (Ramesh & Saralakumari, 2012). Commiphora mukul resin reduced total lipids, phospholipids, cholesterol, glycolipids and more, showing a protective effect on the brain of diabetic rats (G et al., 2015). Extract of guggul can aid in glucose metabolism in diabetes (Bellamkonda et al., 2011). Safe taken in high doses, guggulu may reduce cholesterolemia and LDL levels in those who eat a Western diet (Szapary et al., 2003).


References
Bellamkonda, R., Rasineni, K., Singareddy, S. R., Kasetti, R. B., Pasurla, R., Chippada, A. R., &
Desireddy, S. (2011). Antihyperglycemic and antioxidant activities of alcoholic extract of gum resin in streptozotocin induced diabetic rats. Pathophysiology, 18(4), 255–261. doi:10.1016/j.pathophys.2010.10.002
G, S., B, R., P, M., B, M., Saralakumari, D., Krishnadevaraya, S., … Pradesh, A. (2015).
PROTECTIVE EFFECT OF COMMIPHORA MUKUL GUM RESIN ON BRAIN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. International Journal of Pharmacy and Pharmaceutical Sciences, 7(9), 406–411. Retrieved from http://innovareacademics.in/journals/index.php/ijpps/article/view/7395
Jiang, G., Xiao, X., Zeng, Y., Nagabhushanam, K., Majeed, M., & Xiao, D. (2013). Targeting
beta-catenin signaling to induce apoptosis in human breast cancer cells by z-guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul. BMC Complementary and Alternative Medicine, 13(1), . doi:10.1186/1472-6882-13-203
Ramesh, B., & Saralakumari, D. (2012). Antihyperglycemic, hypolipidemic and antioxidant
activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats. Journal of Physiology and Biochemistry, 68(4), 573–582. doi:10.1007/s13105-012-0175-x
Shen, T., Zhang, L., Wang, Y.-Y., Fan, P.-H., Wang, X.-N., Lin, Z.-M., & Lou, H.-X. (2016).
Steroids from display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis. Bioorganic & Medicinal Chemistry Letters, 22(14), 4801–4806. doi:10.1016/j.bmcl.2012.05.052
Shirazi, Sciences, F. of B., Azad, I., Branch, H., Center, N. R., & Sciences, M. (2015).
Investigation the effect of Commiphora mukul on blood glucose and serum lipid profile in diabetic rats. Armaghane danesh, 19(10), 861–869. Retrieved from http://armaghanj.yums.ac.ir/article-1-76-en.html
Szapary, P. O., Wolfe, M. L., Bloedon, L. T., Cucchiara, A. J., DerMarderosian, A. H.,
Cirigliano, M. D., & Rader, D. J. (2003). Guggulipid for the treatment of Hypercholesterolemia. JAMA, 290(6), 765–772. doi:10.1001/jama.290.6.765
Xiao, M., & Xiao, D. (2012). Extract of Ayurveda medicine. Medicinal Chemistry, 2(105), .
doi:10.4172/2161-0444.1000e105


4
REISHI






Running head: GUGGUL 1