Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2

2006 Carbohydrates U 0500 Indole-Glucosides as Novel Sodium Glucose Co-Transporter 2 (SGLT2) InhibiPart 2. — Compounds (I) show potent in vivo inhibitory activity in ZDF (Zucker 23- 199 tors. Diabetic Fatty) rats. — (ZHANG*, X.; URBANSKI, M.; PATEL, M.; COX, G. G.; ZECK, R. E.; BIAN, H.; CONWAY, B. R.; BEAVERS, M. P.; RYBCZYNSKI, P. J.; DEMAREST, K. T.; Bioorg. Med. Chem. Lett. 16 (2006) 6, 1696-1701; Johnson and Johnson Pharm. Res. Dev., Raritan, NJ 08869, USA; Eng.) — C. Oppel