Is NT-3 a colonic prokinetic—A randomized controlled trial?

volume. Neostigmine increased colonic tone by ~ 35% in all patients, I compliance, i.e. Prl/2 increased from [14.6(1.5) before vs 22.0(2.0) after neostigmine; p0.05 vs vehicle). GR 113808 by' itself had no effect on PISAs activity (Q = 1.24 +_ 0.50). Conclusions: Tegaserod stimulates basal activity of PISAs in a concentration-related manner. Our findings furtber suggest that tegasemd modulates the activity of 'visceral afferents through activation of 5-HT+ receptors. Supported by Novartis Inc and N[H grant DK 58173 (FAM)

Colonic Tone and Compliancein SCI Group CoMrols (Mean• (lOth, ~th %t~le) Spinal cord I n ~ (Mean+$EM) No, of SCI outside 10. 90th %t,e

FastJngtone (ml) 11814 (51,172)

In (Po~/P~ meal volume), -0,5 0 0 9

Pr~ befoceneo~lgmlne (mm Hg)

(-1,1,-0,11)

9,41 0.43 (12,1, 19,0)

22636~

-0,14 0,06"*

14,61.5

4

3

6

*p-ATPase inhibitor thapsigargin (llxM) reduced the amplitude of the contractions in both sets of tissue (% inhibition: C = 65.2 • 13.0; STZ= 54.7 +_9.9, n = 12). The frequency of contractions was also reduced, but this was

A-569

AGA

Abstracts