O040 BIFIDOBACTERIUM BIFIDUM FERMENTED MILK ENHANCES GASTRIC EMPTYING

Geriatrics O040 BIFIDOBACTERIUM BIFIDUM FERMENTED MILK ENHANCES GASTRIC EMPTYING Y. Urita1 , T. Watanabe1 , T. Maeda1 , Y. Sasaki1 , M. Sugimoto1 , F. Ishikawa2 , T. Iino2 , H. Shibahara-Sone2 , R. Akahori2 , S. Mizusawa2 , A. Nose2 , D. Nozaki2 , K. Hirano2 , C. Nonaka3 , T. Yokokura3 . 1 Department of General Medicine and Emergency Care, Toho University, 2 Yakult Central Institute for Microbiological Research, 3 Faculty of Research and Development, Yakult, Tokyo, Japan Rationale: Although some probiotics have potential activity on the improvement of gastritis, it has been unknown whether those alter gastrointestinal function. We also reported that Bifidobacterium bifidum fermented milk (BF-1) could suppress H.pylori activity during ingestion and increase the number of subjects with relief from upper gastrointestinal symptoms. The aim of this study is to investigate the influence of BF-1 ingestion on the gastrointestinal motility. Methods: Ten healthy volunteers (seven men, three women) with a mean age of 27.7 (range 24 29) years were studied. Breath tests were performed in the sitting position after an overnight fast before and after a oneweek beverage-ingestion period. The patients received a liquid test meal (200 cc, 200 kcal) containing 100 mg of 13C-acetate and 12 g of lactulose. Breath samples were collected at 10 min-intervals for 180 min and both 13CO2 and H2 levels were measured. Gastric emptying was expressed as the time of peak excretion. Oro-caecal transit time (OCTT) was defined as the period between the ingestion of lactulose and a H2 peak rise of 10 ppm above the basal value. Results: Unexpectedly, a significant acceleration in breath 13CO2 excretion after a one-week beverageingestion was found by repeated measures ANOVA (p < 0.01), compared to before ingestion. In contrast, there were no significant differences in OCTT before and after ingestion, indicating that a one-week beverageingestion may delay small bowel transit. Conclusion: Bifidobacterium bifidum fermented milk enhances gastric emptying, resulting in the relief of gastrointestinal symptoms. The action of this beverage on gastric emptying is worthy of claiming our attention because this is the first report that probiotics have an ability of enhancing gastric emptying in human. Disclosure of Interest: None declared

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Geriatrics O041 DISEASE-SPECIFIC VERSUS STANDARD NUTRITIONAL SUPPORT FOR THE TREATMENT OF PRESSURE ULCERS IN INSTITUTIONALISED ELDERLY. A RANDOMIZEDCONTROLLED TRIAL E. Cereda1 , A. Gini2 , C. Pusani2 , B. Borghi2 , C. Pedrolli3 , A. Vanotti2 . 1 International Center for the Assessment of Nutritional Status, University of Milan, Milan, 2 Dietetic and Clinical Nutrition Service, ASL Como, Como, 3 Dietetic and Clinical Nutrition Unit, Trento Hospital, Trento, Italy Rationale: Preliminary experiences support improved pressure ulcer (PU) healing from disease-specific formula. Accordingly we aimed to investigate whether a nutrition enriched in protein, arginine, zinc and vitamin C rather than a standard approach is more beneficial to the healing of PUs in institutionalised elderly. Methods: We performed a 12-week follow-up randomizedcontrolled trial in a long-term care setting. 28 institutionalised elderly with stage II, III or IV PUs of recent onset (