Osteosarcoma Models: From Cell Lines to Zebrafish

Hindawi Publishing Corporation Sarcoma Volume 2012, Article ID 417271, 11 pages doi:10.1155/2012/417271

Review Article Osteosarcoma Models: From Cell Lines to Zebrafish Alexander B. Mohseny, Pancras C. W. Hogendoorn, and Anne-Marie Cleton-Jansen Department of Pathology, Leiden University Medical Center, Leiden, P.O. Box 9500, L1-Q, 23000 RC Leiden, The Netherlands Correspondence should be addressed to Anne-Marie Cleton-Jansen, [email protected] Received 2 September 2011; Accepted 24 November 2011 Academic Editor: Luca Sangiorgi Copyright © 2012 Alexander B. Mohseny et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents. The early age of onset might suggest genetic predisposition; however, the vast majority of the tumors are sporadic. Early onset, most often lack of a predisposing condition or lesion, only infrequent (