Poster #183 COGNITIVE BIZARRENESS AS A TRANSNOSOGRAPHIC MARKER OF PSYCHOSIS

Abstracts of the 3rd Biennial Schizophrenia International Research Conference / Schizophrenia Research 136, Supplement 1 (2012) S1–S375

screened reliably for presence of MetS in antipsychotic treated patients. The World Health Organization (WHO) sets a public health action point of BMI 23 kg/m2 to indicate moderate risk for development of cardiovascular disease in Asians. This study aims to investigate the predictive utility of BMI for identification of MetS in patients with schizophrenia treated at a tertiary hospital in Singapore. Methods: One hundred patients with schizophrenia of various Asian ethnicities were recruited into the study. Height, weight, blood pressure and waist circumference were measured and BMI were calculated accordingly. High-density lipoprotein cholesterol (HDL-C), triglycerides and glucose levels were measured from the serum content of a venous blood sample after an overnight fast. We adopted the American Heart Association and National Heart, Lung and Blood Institute (AHA/NHLBI) criterion for MetS and implemented Asian cutoffs for waist circumference as these criteria have been validated in Singapore. A regression model was introduced to examine the effects of BMI on MetS. The optimal predictive value of BMI was examined using receiver operating characteristic (ROC) curve. Sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) at BMI value of 23 kg/m2 , and at optimal predictive value as identified from the ROC curve were tabulated. Results: A total of 46 (46.0%) patients were identified to have MetS. An increasing value of BMI was found to be significantly associated with an increased risk of MetS development (p