Resultados de longo prazo do tratamento fibrinolítico da trombose venosa iliacofemoral por infusão seletiva do ativador de plasminogênio tissular recombinante em baixas doses

CLINICS 2007;62(1):31-40

CLINICAL SCIENCES

LATE RESULTS OF CATHETER-DIRECTED RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR FIBRINOLYTIC THERAPY OF ILIOFEMORAL DEEP VENOUS THROMBOSIS

Ivan Benaduce Casella, Calógero Presti, Ricardo Aun, Joseph Elias Benabou, Pedro Puech-Leão

Casella IB, Presti C, Aun R, Benabou JE, Puech-Leão P. Late results of catheter-directed recombinant tissue plasminogen activator fibrinolytic therapy of iliofemoral deep venous thrombosis. Clinics. 2007;62(1):31-40. PURPOSE: To evaluate the efficacy of catheter-directed low-dose recombinant tissue-type plasminogen activator infusion in the treatment of iliofemoral deep venous thrombosis and prevention of post-thrombotic syndrome. METHOD: Eighteen patients (out of 260 evaluated) with acute iliofemoral deep venous thrombosis and no previous evidence of venous insufficiency were prospectively selected for thrombolytic therapy. Catheter-directed low-dose recombinant tissue-type plasminogen activator (1 mg/h) was infused into the thrombotic segments. RESULTS: Effective fibrinolysis was achieved in 14 of 18 cases, with correlation between effective fibrinolysis and major/ complete resolution of acute signs and symptoms (P