SnapShot: Spinal Cord Development

178 Cell 146, July 8, 2011 ©2011 Elsevier Inc.

DOI 10.1016/j.cell.2011.06.038

See online version for legend and references.

Shh

Pax2

Lhx1

Lhx5

dl6

V3V

V3D

V0V

V0D

V0C

VX

V0V

V0D V2a

MN

pMN

I: Ipsilateral C: Contralateral A: Ascending D: Descending 1: Number of segments

Ia propriospinals

V1 Ia IN

V2a

dl4

V1 Renshaw

dl3

IPSILATERAL CONNECTIONS

V0C

Circuitry

Class I: Shh repressed Class II: Shh induced Class A: TGFβ dependent Class B: TGFβ independent

SYMBOLS

Isl1/2

Gata2 Gata3

Lhx3

Lhx2 FoxD3

Hb9

Ils1

Postmitotic

Bhlhb5

Pitx2

Bhlhb5 Wt1

Drg11 PLCγ

Foxp2

Hb9

Hb9

Hb9

GABA Glycine

V0D

C D 1-3

?

Lhx1

Isl1 HNF-6

Isl2

Isl1

Foxp1

Lmo4 Lhx3

Column

PGC

Visceral

LMCI

LMCm

HMC

MMC

Somatic

Glutamate

C A>D>2

Glutamate V3V

? C A>D>2

Glutamate VX

Muscle

GABA Glycine? Acetylcholine

I A>D>2

I A>D>2

?

I D 1-3

I D 1-3

?

IC D 1-3

GABA Glycine

Glutamate

Glycine GABA

Glycine GABA

Glycine GABA

Glutamate

Acetylcholine

C

C AD

C