Synthesis of sydnonimine derivatives as potential trypanocidal agents

2004

Oxadiazole derivatives

Oxadiazole derivatives R 0290 Synthesis of Sydnonimine Derivatives as Potential Trypanocidal Agents. — Some the new N-substituted sydnonimine derivatives [cf. (V) (5 examples)] are found to 11- 124 of efficiently inhibit the uptake of adenosine with ki values of the same order of magnitude of the km value of the natural substrate adenosine. — (SOULERE, L.; BRINGAUD, F.; HOFFMANN*, P.; J. Heterocycl. Chem. 40 (2003) 5, 943-947; Lab. Synth. Physicochim. Mol. Interet Biol., Univ. Paul Sabatier, F-31062 Toulouse, Fr.; Eng.) — F. Santoso