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Crystal Structure of Mycobacterium tuberculosis Catalase-Peroxidase

Thermodynamics / Molecular Biology / Protein Science / Biological Chemistry / Multidisciplinary / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Mutation / Circular Dichroism / Escherichia coli / Mice / Female / Animals / Fluconazole / Cell Death / Physical sciences / Drug Design / Spectrophotometry / Heme / Membrane transport proteins / Enzyme / CHEMICAL SCIENCES / Electrons / Molecular cloning / Active site / Protein Secondary Structure Prediction / Lysine / X ray diffraction / Time Factors / Antifungal Agents / Protein Conformation / Growth Inhibition / Amino Acid Sequence / Protein Binding / Hydrolysis / Cytoplasm / Ligands / Enzyme Catalysis / Protein Transport / Biochemistry and cell biology / Solvents / Dimerization / Adenosine Triphosphate / Adenosine Diphosphate / Molecular Sequence Data / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Mutation / Circular Dichroism / Escherichia coli / Mice / Female / Animals / Fluconazole / Cell Death / Physical sciences / Drug Design / Spectrophotometry / Heme / Membrane transport proteins / Enzyme / CHEMICAL SCIENCES / Electrons / Molecular cloning / Active site / Protein Secondary Structure Prediction / Lysine / X ray diffraction / Time Factors / Antifungal Agents / Protein Conformation / Growth Inhibition / Amino Acid Sequence / Protein Binding / Hydrolysis / Cytoplasm / Ligands / Enzyme Catalysis / Protein Transport / Biochemistry and cell biology / Solvents / Dimerization / Adenosine Triphosphate / Adenosine Diphosphate / Molecular Sequence Data

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Hydrolysis of aspartic acid phosphoramidate nucleotides: a comparative quantum chemical study

Theory / Quantum Theory / Comparative Study / DNA / Models / Magnesium / Alcohol / Methanol / Physical sciences / Mechanism / D-Aspartic Acid / CHEMICAL SCIENCES / Ion / Active site / Amides / Residue / Calculation / Hydrolysis / Environment / Ions / Amine / Nucleotides / Magnesium / Alcohol / Methanol / Physical sciences / Mechanism / D-Aspartic Acid / CHEMICAL SCIENCES / Ion / Active site / Amides / Residue / Calculation / Hydrolysis / Environment / Ions / Amine / Nucleotides

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

Computational Biology / Kinetics / Enzyme Inhibitors / Multidisciplinary / Antibiotic Resistance / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Escherichia coli / Drug Design / Active site / Substrate Specificity / Fatty Acid / National Cancer Institute / University of Southern California / Cell Wall / In Silico / Protein Quaternary Structure / Ligands / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Escherichia coli / Drug Design / Active site / Substrate Specificity / Fatty Acid / National Cancer Institute / University of Southern California / Cell Wall / In Silico / Protein Quaternary Structure / Ligands

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PAR-3D: a server to predict protein active site residues

Documentation / Computational Biology / Structural Genomics / Biological Sciences / Software / Environmental Sciences / Sequence alignment / Protein structure / Nucleic Acids / Proteins / Enzyme / Information Storage and Retrieval / Protein Sequence Analysis / Active site / Indexation / S100 protein family / Protein Binding / Internet / Ligands / Binding Site / Environmental Sciences / Sequence alignment / Protein structure / Nucleic Acids / Proteins / Enzyme / Information Storage and Retrieval / Protein Sequence Analysis / Active site / Indexation / S100 protein family / Protein Binding / Internet / Ligands / Binding Site

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Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+

Biological Sciences / Crystal structure / Humans / Phosphorylation / Enzyme / Active site / Protein Conformation / NAD / Structural Similarity Index / Life Span / Nicotinic acid / Nucleotides / Active site / Protein Conformation / NAD / Structural Similarity Index / Life Span / Nicotinic acid / Nucleotides

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A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro

Microbiology / Medical Microbiology / HIV / Humans / HIV protease / Drug Design / Human immunodeficiency virus / Spectrum / Active site / Antimicrobial agents / Microbial Sensitivity Tests / Amino Acid Profile / Amino Acid Sequence / Antiviral Activity / Binding Site / Furans / Drug Design / Human immunodeficiency virus / Spectrum / Active site / Antimicrobial agents / Microbial Sensitivity Tests / Amino Acid Profile / Amino Acid Sequence / Antiviral Activity / Binding Site / Furans

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Structure of the Archaeal Pab87 Peptidase Reveals a Novel Self-Compartmentalizing Protease Family

Engineering / Physics / Chemistry / Biology / Medicine / Multidisciplinary / Macromolecular X-Ray Crystallography / Protein Turnover / Archaea / Peptides / PLoS one / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Multidisciplinary / Macromolecular X-Ray Crystallography / Protein Turnover / Archaea / Peptides / PLoS one / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation

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Kinetic Mechanism of Pyranose 2-Oxidase from Trametes multicolor

Biochemistry / Catalysis / Kinetics / Glucose / Temperature / Enzyme / Steady state / Hydrogen Peroxide / Active site / Buffers / Oxygen / Substrate Specificity / Isotope effect / Phosphates / Protein Conformation / Protein Binding / Hydrogen-Ion Concentration / Oxidation-Reduction / Flavins / Biochemistry and cell biology / Enzyme / Steady state / Hydrogen Peroxide / Active site / Buffers / Oxygen / Substrate Specificity / Isotope effect / Phosphates / Protein Conformation / Protein Binding / Hydrogen-Ion Concentration / Oxidation-Reduction / Flavins / Biochemistry and cell biology

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Probing active-site residues of pyranose 2-oxidase from Trametes multicolor by semi-rational protein design

Kinetics / Biotechnology / Industrial Biotechnology / Gene expression / Protein Engineering / Environmental Biotechnology / Biocatalysis / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction / Environmental Biotechnology / Biocatalysis / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction

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Yeast d-Amino Acid Oxidase: Structural Basis of its Catalytic Properties

Molecular Biology / Kinetics / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Molecular / Crystal structure / Enzyme / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Yeasts / D structure / Glutathione Reductase / Catalytic Activity / Biochemistry and cell biology / Dimerization / Crystal structure / Enzyme / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Yeasts / D structure / Glutathione Reductase / Catalytic Activity / Biochemistry and cell biology / Dimerization

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Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Organic Chemistry / Kinetics / Modeling / Crystallization / Enzyme Inhibitors / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase

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A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism

Directed evolution / Biological Engineering / Electron Transfer / Biological / Enzyme / Energy Production / Active site / Metabolic pathway / Genetic Selection / Energy Production / Active site / Metabolic pathway / Genetic Selection

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Molecular pathogenesis of a disease: structural consequences of aspartylglucosaminuria mutations

Confocal Microscopy / Biological Sciences / DNA / Humans / Mutation / Human Molecular Genetics / Endoplasmic Reticulum / Fluorescent Antibody Technique / Active site / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Body of Knowledge / Human Fibroblasts / Lysosomes / Ligands / Lysosomal Storage Diseases / Human Molecular Genetics / Endoplasmic Reticulum / Fluorescent Antibody Technique / Active site / Amino Acid Profile / Transfection / Protein Conformation / Amino Acid Sequence / Body of Knowledge / Human Fibroblasts / Lysosomes / Ligands / Lysosomal Storage Diseases

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Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis

Multidisciplinary / Macromolecular X-Ray Crystallography / Crystal structure / Tuberculosis / Sequence alignment / Mycobacterium tuberculosis / Lipid metabolism / PLoS one / Enzyme / Active site / Protein Secondary Structure Prediction / Esterases / Amino Acid Sequence / D structure / Hydrolysis / Mycobacterium tuberculosis / Lipid metabolism / PLoS one / Enzyme / Active site / Protein Secondary Structure Prediction / Esterases / Amino Acid Sequence / D structure / Hydrolysis

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