Trypanocidal Agents

A bioactive biflavonoid from Campnosperma panamense

Complementary and Alternative Medicine / Plant Biology / Pharmacognosy / Flavonoids / Phytotherapy / Humans / Animals / Anacardiaceae / Chagas disease / Plant extracts / Trypanosoma Cruzi / Antimalarials / Fitoterapia / Trypanocidal Agents / Polyphenol / Plant Leaves / Humans / Animals / Anacardiaceae / Chagas disease / Plant extracts / Trypanosoma Cruzi / Antimalarials / Fitoterapia / Trypanocidal Agents / Polyphenol / Plant Leaves

Biological characterization of a beta-galactosidase expressing clone of Trypanosoma cruzi CL strain

Medical Microbiology / Cercopithecus aethiops / Mice / Animals / Trypanosoma Cruzi / Nifurtimox / Trypanocidal Agents / Vero cells / Nifurtimox / Trypanocidal Agents / Vero cells

Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi

Medical Microbiology / Confocal Microscopy / Cell line / Animals / Natural Product / Plant extracts / Trypanosoma Cruzi / Diterpenes / Molecular Marker / Reproducibility of Results / Trypanocidal Agents / Lethal Dose / Plant extracts / Trypanosoma Cruzi / Diterpenes / Molecular Marker / Reproducibility of Results / Trypanocidal Agents / Lethal Dose

Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi

Medical Microbiology / Confocal Microscopy / Cell line / Animals / Natural Product / Plant extracts / Trypanosoma Cruzi / Diterpenes / Molecular Marker / Reproducibility of Results / Trypanocidal Agents / Lethal Dose / Plant extracts / Trypanosoma Cruzi / Diterpenes / Molecular Marker / Reproducibility of Results / Trypanocidal Agents / Lethal Dose

Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities

Phytochemistry / Enzyme Inhibitors / Flavonoids / Biological Sciences / Animals / CHEMICAL SCIENCES / Trypanosoma Cruzi / Trypanocidal Agents / Recombinant Proteins / CHEMICAL SCIENCES / Trypanosoma Cruzi / Trypanocidal Agents / Recombinant Proteins

New potent 5-nitrofuryl derivatives as inhibitors of Trypanosoma cruzi growth. 3D-QSAR (CoMFA) studies

Organic Chemistry / Mass Spectrometry / Modeling / Prediction / Magnetic Resonance Spectroscopy / Growth / QSAR / Animals / Quantitative Structure Activity Relationship / Hydrogen Bond / European / Trypanosoma Cruzi / Molecular Model / Three Dimensional / Trypanocidal Agents / Quntitative Thin Layer Chromatography / Chemical Synthesis / Growth / QSAR / Animals / Quantitative Structure Activity Relationship / Hydrogen Bond / European / Trypanosoma Cruzi / Molecular Model / Three Dimensional / Trypanocidal Agents / Quntitative Thin Layer Chromatography / Chemical Synthesis

5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: Preliminary in vivo studies

Organic Chemistry / Mice / Female / Animals / Chagas disease / European / Trypanosoma Cruzi / Nifurtimox / Trypanocidal Agents / Murine Model / Structure activity Relationship / Acute Toxicity / Chemical Structure / European / Trypanosoma Cruzi / Nifurtimox / Trypanocidal Agents / Murine Model / Structure activity Relationship / Acute Toxicity / Chemical Structure

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

Microbiology / Immunology / Medical Microbiology / Innate immunity / Humans / Genetically modified organisms / Trypanosoma brucei / Trypanosoma brucei brucei / Human Serum / Host Pathogen Interactions / Trypanocidal Agents / Blood Proteins / Genetically modified organisms / Trypanosoma brucei / Trypanosoma brucei brucei / Human Serum / Host Pathogen Interactions / Trypanocidal Agents / Blood Proteins

Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents

Organic Chemistry / Humans / Molecular docking / Chagas disease / Enzyme / Trypanosoma Cruzi / Cysteine endopeptidases / Molecular Conformation / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Erythrocytes / Cysteine Proteinase Inhibitors / Trypanosoma Cruzi / Cysteine endopeptidases / Molecular Conformation / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Erythrocytes / Cysteine Proteinase Inhibitors

Arylfurans as potential Trypanosoma cruzi trypanothione reductase inhibitors

Medical Microbiology / Enzyme Inhibitors / Mice / Animals / Male / Chagas disease / Total Synthesis / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Furans / Chagas disease / Total Synthesis / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Furans

Trypanosomicidal Kaurane Diterpenes from Wedelia paludosa

Parasitology / Natural Products / Complementary and Alternative Medicine / Plant Biology / Mice / Animals / Asteraceae / Trypanosoma Cruzi / Diterpenes / Trypanocidal Agents / Kaurane Diterpenes / Animals / Asteraceae / Trypanosoma Cruzi / Diterpenes / Trypanocidal Agents / Kaurane Diterpenes

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Treatment / Drug development / Macromolecular X-Ray Crystallography / In Vitro / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure

Natural Chromenes and Chromene Derivatives as Potential Anti-trypanosomal Agents

Plant Biology / Animals / Biological / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Piper / Structure activity Relationship / Piper

A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole

Medical Microbiology / Phylogeny / Humans / Animals / Drug Resistance / Membrane transport proteins / Genotype / Trypanosoma Cruzi / Trypanocidal Agents / Membrane transport proteins / Genotype / Trypanosoma Cruzi / Trypanocidal Agents

Quinol derivatives as potential trypanocidal agents

Organic Chemistry / Cell line / Humans / Drug Delivery Systems / Trypanosoma brucei brucei / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Triazines / Molecular Structure / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Triazines / Molecular Structure

Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi

Medical Microbiology / Confocal Microscopy / Cell line / Animals / Natural Product / Plant extracts / Trypanosoma Cruzi / Diterpenes / Molecular Marker / Reproducibility of Results / Trypanocidal Agents / Lethal Dose / Plant extracts / Trypanosoma Cruzi / Diterpenes / Molecular Marker / Reproducibility of Results / Trypanocidal Agents / Lethal Dose

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