Drug Design - Page 4

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Organic Chemistry / X Rays / Propionic Acid / Drug Design / X ray diffraction / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure

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Grid-Enabled High-Throughput <emphasis emphasistype=\"italic\">In Silico</emphasis> Screening Against Influenza A Neuraminidase

Biomedical Engineering / Drug Discovery / Virtual screening / influenza A / High throughput screening / Drug Design / Lessons Learned / Very high throughput / influenza A virus / Large Scale / In Silico / Electrical And Electronic Engineering / Drug Design / Lessons Learned / Very high throughput / influenza A virus / Large Scale / In Silico / Electrical And Electronic Engineering

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Artificial neural networks for computer-based molecular design

Back Propagation / Radial Basis Function / Computer Aided Design / Neural Network / Sequence Analysis / Dimension Reduction / Software / Drug Design / Quantitative Structure Activity Relationship / Feature Extraction / Adaptive Resonance Theory / Principle component analysis / Target Identification / Associative Memory / Least Mean Square / Three Dimensional / Molecular Conformation / Structure activity Relationship / Artificial Neural Network / Biochemistry and cell biology / Molecular Structure / Dimension Reduction / Software / Drug Design / Quantitative Structure Activity Relationship / Feature Extraction / Adaptive Resonance Theory / Principle component analysis / Target Identification / Associative Memory / Least Mean Square / Three Dimensional / Molecular Conformation / Structure activity Relationship / Artificial Neural Network / Biochemistry and cell biology / Molecular Structure

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Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase

Organic Chemistry / Drug Design / Hepatitis C Virus / Enzyme / Microbial Sensitivity Tests / Structure activity Relationship / RNA Dependent RNA Polymerase / Antiviral Agents / Molecular Structure / Structure activity Relationship / RNA Dependent RNA Polymerase / Antiviral Agents / Molecular Structure

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Associative neural network

Algorithms / Pharmaceutical Chemistry / Software / Brain / Humans / Animals / Drug Design / Quantitative Structure Activity Relationship / Theoretical Models / Short Term Memory / Biochemistry and cell biology / Animals / Drug Design / Quantitative Structure Activity Relationship / Theoretical Models / Short Term Memory / Biochemistry and cell biology

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Ni-DTPA doped agarose gel—A phantom material for Gd-DTPA enhancement measurements

Cognitive Science / Biomedical Engineering / Magnetic Resonance Imaging / Drug interactions / Humans / Structural equation models / Drug Design / Temperature / Nickel / Clinical Sciences / Gels / Gadolinium / Time Factors / Solutions / Organometallic Compounds / Contrast Media / Sepharose / Structural equation models / Drug Design / Temperature / Nickel / Clinical Sciences / Gels / Gadolinium / Time Factors / Solutions / Organometallic Compounds / Contrast Media / Sepharose

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Conserved Fungal Genes as Potential Targets for Broad-Spectrum Antifungal Drug Discovery

Computational Biology / Drug Discovery / Biological Sciences / Drug Design / Candida albicans / Spectrum / Antifungal Agents / Microbial Sensitivity Tests / Base Sequence / Eukaryotic Cell / Spectrum / Antifungal Agents / Microbial Sensitivity Tests / Base Sequence / Eukaryotic Cell

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Cancer stem cell-like cells from a single cell of oral squamous carcinoma cell lines

Radiation Therapy / Cell Culture / Cell line / Humans / Wnt Signaling / Drug Design / Paclitaxel / Single Cell / Cancer Stem Cell / Oral Squamous Cell Carcinoma (OSCC) / Mouth Neoplasms / Oral Squamous Cell Carcinoma / Cell Proliferation / Biochemistry and cell biology / Anticancer Drug / Differential expression / Drug Design / Paclitaxel / Single Cell / Cancer Stem Cell / Oral Squamous Cell Carcinoma (OSCC) / Mouth Neoplasms / Oral Squamous Cell Carcinoma / Cell Proliferation / Biochemistry and cell biology / Anticancer Drug / Differential expression

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2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers

Organic Chemistry / Macromolecular X-Ray Crystallography / Fluorescence Resonance Energy Transfer / Computer Simulation / Drug Design / Telomere / Triazoles / Thiazoles / Transition Temperature / Telomere / Triazoles / Thiazoles / Transition Temperature

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Polyamorphism: a pharmaceutical science perspective

Pharmacy / Crystallization / Pharmacology and Clinical pharmacy / Drug Design / Theoretical Models / Pharmaceutical preparations / Isomerism / Pharmaceutical preparations / Isomerism

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Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA

Structural Biology / Genomics / Proteomics / Biophysical Chemistry / Structural Genomics / Protein Targeting / Biological Sciences / Glutamate / Tuberculosis / Mycobacterium tuberculosis / Physical sciences / Drug Design / Drug Delivery Systems / CHEMICAL SCIENCES / Thioredoxin / Protein Conformation / Drug Targeting / Structure Determination / Protein Targeting / Biological Sciences / Glutamate / Tuberculosis / Mycobacterium tuberculosis / Physical sciences / Drug Design / Drug Delivery Systems / CHEMICAL SCIENCES / Thioredoxin / Protein Conformation / Drug Targeting / Structure Determination

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Comparative structural analysis of two proteins belonging to quorum sensing system in Vibrio cholerae

Biofilms / Molecular Dynamics Simulation / Signal Transduction / Communication System / Homology Modeling / Vibrio cholerae / Drug Design / Quorum Sensing / Molecular docking / Structure Analysis / Protein Binding / Drug Targeting / Molecular Dynamic Simulation / Environmental Parameter / Computational Method / Biochemistry and cell biology / Vibrio cholerae / Drug Design / Quorum Sensing / Molecular docking / Structure Analysis / Protein Binding / Drug Targeting / Molecular Dynamic Simulation / Environmental Parameter / Computational Method / Biochemistry and cell biology

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Rutoxyl [rutin/4-acetamide-1-hydroxy-2,2,6,6-tetramethylpiperidinium] is a new member of the class of semi-natural products of high pharmacological potency

Antioxidants / Animals / Natural Product / Male / Drug Design / Rats / Wistar Rats / Biochemistry and molecular biology / Structure activity Relationship / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Piperidines / Rats / Wistar Rats / Biochemistry and molecular biology / Structure activity Relationship / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Piperidines

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Chemical Adaptor Systems

Chemistry / Drug Design / Drug Delivery Systems / CHEMICAL SCIENCES / Neoplasms / Cyclization / Antineoplastic Agents / Molecular Structure / Cyclization / Antineoplastic Agents / Molecular Structure

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Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria

Gene Silencing / Humans / Animals / Drug Design / Biochemical / Protease Inhibitors / Presenilins / Plasmodium falciparum / Antimalarials / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / Carbamates / Biochemistry and cell biology / Protease Inhibitors / Presenilins / Plasmodium falciparum / Antimalarials / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / Carbamates / Biochemistry and cell biology

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Oximinoarylsulfonamides as potent HIV protease inhibitors

Organic Chemistry / Kinetics / HIV protease / Drug Design / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Carbamates / Bioorganic and medicinal Chemistry / Structure activity Relationship / Carbamates

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