Protein Binding

Esterase 1 is a Novel Transcriptional Repressor of Growth Hormone Receptor Gene Expression: A Unique Noncatalytic Role for a Carboxyesterase Protein

Molecular endocrinology / Biocatalysis / Biological Sciences / Molecular / Cell line / Humans / Liver / Mice / Animals / Cell nucleus / Molecular weight / Protein isoforms / Amino Acid Sequence / Protein Binding / Protein Transport / Response Elements / Gene Expression Regulation / Dietary fats / Molecular Sequence Data / Humans / Liver / Mice / Animals / Cell nucleus / Molecular weight / Protein isoforms / Amino Acid Sequence / Protein Binding / Protein Transport / Response Elements / Gene Expression Regulation / Dietary fats / Molecular Sequence Data

GAMESS As a Free Quantum-Mechanical Platform for Drug Research

Computational Biology / Quantum Theory / Drug Discovery / Software / Drug Design / Protein Binding / Ligands / Protein Binding / Ligands

Poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as innate immune system activators

Complement activation / Nanoparticles / Innate immunity / Dendritic Cells / Toll like receptor signaling / Biological Sciences / Toll Like Receptors / Vaccine / Dendritic cell / Maleic Anhydride / Group / Polyethylenes / Protein Binding / Innate Immune System / Complement fixation test / Biological Sciences / Toll Like Receptors / Vaccine / Dendritic cell / Maleic Anhydride / Group / Polyethylenes / Protein Binding / Innate Immune System / Complement fixation test

hCOA3 Stabilizes Cytochrome c Oxidase 1 (COX1) and Promotes Cytochrome c Oxidase Assembly in Human Mitochondria

Membrane Proteins / Mitochondria / Biological Chemistry / Biological Sciences / Humans / CHEMICAL SCIENCES / HeLa cells / Protein Binding / Mitochondrial Proteins / CHEMICAL SCIENCES / HeLa cells / Protein Binding / Mitochondrial Proteins

In vitro display technologies reveal novel biopharmaceutics

Physiology / Protein Engineering / Protein-Protein Interaction / Infectious Disease / Phage display / Biopharmaceutics / Medical Physiology / Enzyme / Protein Binding / Biochemistry and cell biology / Biopharmaceutics / Medical Physiology / Enzyme / Protein Binding / Biochemistry and cell biology

hCOA3 Stabilizes Cytochrome c Oxidase 1 (COX1) and Promotes Cytochrome c Oxidase Assembly in Human Mitochondria

Membrane Proteins / Mitochondria / Biological Chemistry / Biological Sciences / Humans / CHEMICAL SCIENCES / HeLa cells / Protein Binding / Mitochondrial Proteins / CHEMICAL SCIENCES / HeLa cells / Protein Binding / Mitochondrial Proteins

Pistagremic acid, a glucosidase inhibitor from Pistacia integerrima

Phytochemistry / Complementary and Alternative Medicine / Plant Biology / Pharmacognosy / Saccharomyces cerevisiae / Animals / Docking / Intestines / Rats / Fitoterapia / Pistacia / Protein Binding / Molecular Structure / Triterpenes / Animals / Docking / Intestines / Rats / Fitoterapia / Pistacia / Protein Binding / Molecular Structure / Triterpenes

Antinuclear antibodies: A contemporary nomenclature using HEp-2 cells

Immunology / Autoimmunity / Image Classification / European Commission / Humans / Autoimmune diseases / Europe / Image recognition / Connective Tissue Disease / Biological markers / Lupus Erythematosus / Digital Image / Growth Factor / Protein Binding / Protein Transport / Autoimmune diseases / Europe / Image recognition / Connective Tissue Disease / Biological markers / Lupus Erythematosus / Digital Image / Growth Factor / Protein Binding / Protein Transport

Probing active-site residues of pyranose 2-oxidase from Trametes multicolor by semi-rational protein design

Kinetics / Biotechnology / Industrial Biotechnology / Gene expression / Protein Engineering / Environmental Biotechnology / Biocatalysis / Biological Sciences / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Galactose Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction / Molecular Sequence Data / Environmental Biotechnology / Biocatalysis / Biological Sciences / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Galactose Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction / Molecular Sequence Data

ADAM8 as a drug target in pancreatic cancer

Membrane Proteins / Multidisciplinary / Nature / Western blotting / Signal Transduction / Humans / Mice / Animals / Cyclic peptides / Phosphorylation / Neoplasm Invasiveness / Protein Binding / Hydroxamic Acids / Communications / Molecular Targeted Therapy / Nature Communications / Extracellular Space / Matrix Metalloproteinase / Humans / Mice / Animals / Cyclic peptides / Phosphorylation / Neoplasm Invasiveness / Protein Binding / Hydroxamic Acids / Communications / Molecular Targeted Therapy / Nature Communications / Extracellular Space / Matrix Metalloproteinase

Human malaria parasites display a receptor for activated C kinase ortholog

Fluorescence Microscopy / Cell Cycle / Cell Signaling / Confocal Microscopy / Danio rerio / Western blotting / Signal Transduction / Humans / Animals / Biochemical / Life Cycle / Molecular cloning / Plasmodium falciparum / Amino Acid Profile / Molecular weight / Amino Acid Sequence / Base Sequence / Erythrocytes / Protein Binding / Chlamydomonas Reinhardtii / Full Length Movies / Oligonucleotides / Biochemistry and cell biology / Molecular Sequence Data / Western blotting / Signal Transduction / Humans / Animals / Biochemical / Life Cycle / Molecular cloning / Plasmodium falciparum / Amino Acid Profile / Molecular weight / Amino Acid Sequence / Base Sequence / Erythrocytes / Protein Binding / Chlamydomonas Reinhardtii / Full Length Movies / Oligonucleotides / Biochemistry and cell biology / Molecular Sequence Data

Lipidic phase membrane protein serial femtosecond crystallography

Technology / Membrane Proteins / Macromolecular X-Ray Crystallography / Biological Sciences / X Rays / Protein Conformation / Lipid bilayers / Membrane Protein / Protein Binding / Protein Conformation / Lipid bilayers / Membrane Protein / Protein Binding

A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands

Organic Chemistry / Kinetics / Pharmaceutical Chemistry / Humans / Drug Design / Serotonin Receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Ligands / Molecular Structure / Tryptamines / Serotonin Receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Ligands / Molecular Structure / Tryptamines

Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1: UNUSUAL FEATURES AND SPECTRAL RESPONSE

Water / Kinetics / Biological Chemistry / Biological Sciences / Brain / Humans / Mutation / Nitriles / Cholesterol / Animals / Iron / Spectrophotometry / Heme / CHEMICAL SCIENCES / Cattle / Molecular Conformation / Protein Binding / Antineoplastic Agents / Site-directed Mutagenesis / Humans / Mutation / Nitriles / Cholesterol / Animals / Iron / Spectrophotometry / Heme / CHEMICAL SCIENCES / Cattle / Molecular Conformation / Protein Binding / Antineoplastic Agents / Site-directed Mutagenesis

Myeloperoxidase attracts neutrophils by physical forces

Hematology / Peroxidase / Humans / Mice / Animals / Blood / Male / Physical processes / Clinical Sciences / Neutrophils / Peroxidases / Surface Properties / Force / Protein Binding / Myeloperoxidase / Static Electricity / Blood / Male / Physical processes / Clinical Sciences / Neutrophils / Peroxidases / Surface Properties / Force / Protein Binding / Myeloperoxidase / Static Electricity
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