Signal Transduction

Cdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage

DNA damage / DNA repair / Signal Transduction / Cell and Molecular Biology / Biological Sciences / Cell line / Humans / Mutation / Phosphorylation / Cell Cycle Proteins / DNA binding proteins / Cell line / Humans / Mutation / Phosphorylation / Cell Cycle Proteins / DNA binding proteins

Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway

Enzyme Inhibitors / Prefrontal Cortex / Signal Transduction / Animals / Male / Rats / Endocannabinoids / Pyrazoles / Action Potentials / Carbamates / Benzamides / Piperidines / Rats / Endocannabinoids / Pyrazoles / Action Potentials / Carbamates / Benzamides / Piperidines

The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor

Cellular Biology / Signal Transduction / Biological Sciences / Molecular and cellular biology / Humans / Animals / Male / Prostate / Aged / Middle Aged / Cell nucleus / Adult / Animals / Male / Prostate / Aged / Middle Aged / Cell nucleus / Adult

A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of Clinical Brain Tumor Specimens

Cancer / Immunohistochemistry / Signal Transduction / Brain Tumor / Humans / Glioblastoma / Phosphorylation / Single Cell / Reproducibility of Results / Brain Neoplasms / Glioblastoma / Phosphorylation / Single Cell / Reproducibility of Results / Brain Neoplasms

Phosducin induces a structural change in transducin βγ

Structure / Macromolecular X-Ray Crystallography / Signal Transduction / Biological Sciences / Crystal structure / Sequence alignment / Animals / Retina / Structural Change / Electron Density / CHEMICAL SCIENCES / Cattle / Protein Secondary Structure Prediction / Protein Conformation / G protein / Amino Acid Sequence / Protein Binding / Gtp Binding Proteins / Transducin / Sequence alignment / Animals / Retina / Structural Change / Electron Density / CHEMICAL SCIENCES / Cattle / Protein Secondary Structure Prediction / Protein Conformation / G protein / Amino Acid Sequence / Protein Binding / Gtp Binding Proteins / Transducin

Myosin as a potential redox-sensor: an in vitro study

Physiology / Catalysis / Western blotting / Signal Transduction / Free Radical / Muscle / Animals / Glutathione / Protein structure / Trypsin / Skeletal Muscle / Rats / Redox Regulation / Protein Conformation / In Vitro Studies / Quantum Yield / Oxidation-Reduction / Biochemistry and cell biology / Functional Dependency / Muscle / Animals / Glutathione / Protein structure / Trypsin / Skeletal Muscle / Rats / Redox Regulation / Protein Conformation / In Vitro Studies / Quantum Yield / Oxidation-Reduction / Biochemistry and cell biology / Functional Dependency

Hypoxia Response in Asthma

Inflammation / Asthma / Apoptosis / Signal Transduction / Chemokines and chemokine receptors / RNA interference / Mice / Animals / Male / Lung / RNA interference / Mice / Animals / Male / Lung

Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum

Inorganic Chemistry / Signal Transduction / Phosphorylation / European / Plasmodium falciparum / Protein Kinase / Biochemistry and cell biology / Protein Kinase / Biochemistry and cell biology

Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells

Physiology / Skeletal muscle biology / Protein synthesis / Signal Transduction / Cell line / Protein Kinases / Glucose / Animals / Medical Physiology / Amino Acids / Skeletal Muscle / Rats / Amino Acid Profile / Dependable Systems / Plasma Membrane / Ceramides / Biochemistry and cell biology / Protein Kinases / Glucose / Animals / Medical Physiology / Amino Acids / Skeletal Muscle / Rats / Amino Acid Profile / Dependable Systems / Plasma Membrane / Ceramides / Biochemistry and cell biology

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Adrenergic Responses to Stress

Multidisciplinary / Signal Transduction / Humans / Epinephrine / Animals / Rats / Physiological Stress Markers / Physical Restraint / Gene Expression Regulation / Adrenal Medulla / Rats / Physiological Stress Markers / Physical Restraint / Gene Expression Regulation / Adrenal Medulla

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases

Microbiology / Medical Microbiology / Cancer stem cells / Cell Biology / Cancer Biology / Cancer Research / Signal Transduction / Humans / Mice / Animals / Giardiasis / Entamoeba histolytica / Benzamides / Cancer Research / Signal Transduction / Humans / Mice / Animals / Giardiasis / Entamoeba histolytica / Benzamides

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Comparative structural analysis of two proteins belonging to quorum sensing system in Vibrio cholerae

Biofilms / Molecular Dynamics Simulation / Signal Transduction / Communication System / Homology Modeling / Vibrio cholerae / Drug Design / Quorum Sensing / Molecular docking / Structure Analysis / Protein Binding / Drug Targeting / Molecular Dynamic Simulation / Environmental Parameter / Computational Method / Biochemistry and cell biology / Vibrio cholerae / Drug Design / Quorum Sensing / Molecular docking / Structure Analysis / Protein Binding / Drug Targeting / Molecular Dynamic Simulation / Environmental Parameter / Computational Method / Biochemistry and cell biology

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases

Microbiology / Medical Microbiology / Cancer stem cells / Cell Biology / Cancer Biology / Cancer Research / Signal Transduction / Humans / Mice / Animals / Giardiasis / Entamoeba histolytica / Benzamides / Cancer Research / Signal Transduction / Humans / Mice / Animals / Giardiasis / Entamoeba histolytica / Benzamides

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