Structure activity Relationship - Page 10

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

Organic Chemistry / Modeling / Prediction / Pharmacokinetics / Molecular modeling / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity

Download

Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis

Download

Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis

Download

A Prodomain Peptide of Plasmodium falciparum Cysteine Protease (Falcipain-2) Inhibits Malaria Parasite Development

Organic Chemistry / Medicinal Chemistry / Animals / Peptides / Medicinal / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins

Download

A prodomain peptide of plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development

Organic Chemistry / Medicinal Chemistry / Animals / Peptides / Medicinal / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins

Download

Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells

Complementary and Alternative Medicine / Chromatography / Plant Biology / Mass Spectrometry / Breast Cancer / Ethnopharmacology / Medicinal Plants / Magnetic Resonance Spectroscopy / Apoptosis / Western blotting / Caspases / Humans / Lancet / Caco-2 cells / Neoplasms / Asclepiadaceae / Acylation / Cell Proliferation / Structure activity Relationship / Structural Similarity Index / Cell Survival / Glycosides / Molecular Structure / Cysteine Proteinase Inhibitors / MTT assay / Neutral Red / Ethnopharmacology / Medicinal Plants / Magnetic Resonance Spectroscopy / Apoptosis / Western blotting / Caspases / Humans / Lancet / Caco-2 cells / Neoplasms / Asclepiadaceae / Acylation / Cell Proliferation / Structure activity Relationship / Structural Similarity Index / Cell Survival / Glycosides / Molecular Structure / Cysteine Proteinase Inhibitors / MTT assay / Neutral Red

Download

8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands

Organic Chemistry / Humans / Structure activity Relationship / Recombinant Proteins / Adenine / Ligands / Molecular Structure / Ligands / Molecular Structure

Download

A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system

Organic Chemistry / Cytotoxicity / Ovarian Cancer / Cell line / In Vitro / Humans / Female / Male / Spectrum / Neoplasms / Biological activity / Ovary / Antitumor Activity / Structure activity Relationship / Chemical Synthesis / Antineoplastic Agents / Heterocyclic compounds / Humans / Female / Male / Spectrum / Neoplasms / Biological activity / Ovary / Antitumor Activity / Structure activity Relationship / Chemical Synthesis / Antineoplastic Agents / Heterocyclic compounds

Download

N 1 -Benzoyl- N 2 -[1-(1-naphthyl)ethyl]- trans -1,2-diaminocyclohexanes: Development of 4-Chlorophenylcarboxamide (Calhex 231) as a New Calcium Sensing Receptor Ligand Demonstrating Potent Calcilytic Activity

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Animals / Calcium Sensing Receptor / Rats / Medicinal / Protein Conformation / Structure activity Relationship / Ligands / Benzamides / Molecular Structure / Rats / Medicinal / Protein Conformation / Structure activity Relationship / Ligands / Benzamides / Molecular Structure

Download

Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents

Organic Chemistry / Humans / Cell Death / Quinones / Peptides / Biomimetic materials / Cell Proliferation / Structure activity Relationship / Cell Survival / Antineoplastic Agents / Oxidation-Reduction / Molecular Structure / Biomimetic materials / Cell Proliferation / Structure activity Relationship / Cell Survival / Antineoplastic Agents / Oxidation-Reduction / Molecular Structure

Download

A natural product based DOS library of hybrid systems

Organic Chemistry / Malaria / Drug Discovery / Humans / Plasmodium falciparum / Antimalarials / DoS / Structure activity Relationship / Erythrocytes / Molecular Structure / Antimalarials / DoS / Structure activity Relationship / Erythrocytes / Molecular Structure

Download

Kojic acid–tripeptide amide as a new tyrosinase inhibitor

Peptide Science / Enzyme Inhibitors / Stability / Biological Sciences / Biopolymers / Kojic Acid / CHEMICAL SCIENCES / Structure activity Relationship / Drug Stability / Molecular Structure / Kojic Acid / CHEMICAL SCIENCES / Structure activity Relationship / Drug Stability / Molecular Structure

Download

Probing active-site residues of pyranose 2-oxidase from Trametes multicolor by semi-rational protein design

Kinetics / Biotechnology / Industrial Biotechnology / Gene expression / Protein Engineering / Environmental Biotechnology / Biocatalysis / Biological Sciences / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Galactose Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction / Molecular Sequence Data / Environmental Biotechnology / Biocatalysis / Biological Sciences / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Galactose Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction / Molecular Sequence Data

Download

Potent 4-amino-5-azaindole factor VIIa inhibitors

Organic Chemistry / PT / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Serine Protease / Tissue Factor / Molecular Structure / Selectivity / Chemical Synthesis / Serine Protease / Tissue Factor / Molecular Structure / Selectivity

Download

Fatty acid import into mitochondria

Mitochondria / Intelligent Transport System / Biological Sciences / Humans / Fatty acids / Energy demand / Animals / Physical sciences / Fatty Acid Oxidation / Long Chain Fatty Acid / Enzyme / L-carnitine / Fatty Acid / Structure activity Relationship / Oxidation-Reduction / Acetyl CoA Carboxylase / Energy demand / Animals / Physical sciences / Fatty Acid Oxidation / Long Chain Fatty Acid / Enzyme / L-carnitine / Fatty Acid / Structure activity Relationship / Oxidation-Reduction / Acetyl CoA Carboxylase

Download

Para-methylthioamphetamine, a new amphetamine designer drug of abuse

Humans / Case Study / Male / Adult / Drugs of Abuse / Amphetamines / Designer Drugs / Structure activity Relationship / Enzyme Linked Immunosorbent Assay / Amphetamines / Designer Drugs / Structure activity Relationship / Enzyme Linked Immunosorbent Assay

Download