Structure activity Relationship

A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition

Molecular modeling / Molecular Dynamics / Humans / Escherichia coli / Animals / Molecular cloning / Ixodidae / Salivary Gland / Structure activity Relationship / Recombinant Proteins / Bioactive Compound / Molecular Dynamic Simulation / Factor Xa / cDNA library / Biochemistry and cell biology / Molecular cloning / Ixodidae / Salivary Gland / Structure activity Relationship / Recombinant Proteins / Bioactive Compound / Molecular Dynamic Simulation / Factor Xa / cDNA library / Biochemistry and cell biology

A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition

Molecular modeling / Molecular Dynamics / Humans / Escherichia coli / Animals / Molecular cloning / Ixodidae / Salivary Gland / Structure activity Relationship / Recombinant Proteins / Bioactive Compound / Molecular Dynamic Simulation / Factor Xa / cDNA library / Biochemistry and cell biology / Molecular cloning / Ixodidae / Salivary Gland / Structure activity Relationship / Recombinant Proteins / Bioactive Compound / Molecular Dynamic Simulation / Factor Xa / cDNA library / Biochemistry and cell biology

A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands

Organic Chemistry / Kinetics / Pharmaceutical Chemistry / Humans / Drug Design / Serotonin Receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Ligands / Molecular Structure / Tryptamines / Serotonin Receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Ligands / Molecular Structure / Tryptamines

Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors

Organic Chemistry / Drug Discovery / Humans / Metabolic diseases / Mice / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase

Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors

Organic Chemistry / Drug Discovery / Humans / Metabolic diseases / Mice / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase

2‘- O -[2-(Amino)-2-oxoethyl] Oligonucleotides

Organic / Nucleic Acids / CHEMICAL SCIENCES / Structure activity Relationship / Drug Stability

Discovery of a series of aminopiperidines as novel iNOS inhibitors

Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Amines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines

Discovery of a series of aminopiperidines as novel iNOS inhibitors

Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Amines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines

Na+,2Cl−,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives

Hypertension / Blood Pressure / Diuretics / Animals / Male / Potassium / Rats / Sodium / Chlorine / Structure activity Relationship / Erythrocytes / Potassium / Rats / Sodium / Chlorine / Structure activity Relationship / Erythrocytes

IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines

Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

IRAK-4 inhibitors. Part 1: A series of amides

Organic Chemistry / Enzyme Inhibitors / Humans / Drug Design / SAR / Solubility / Docking / Amides / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Suzuki Reaction / Solubility / Docking / Amides / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Suzuki Reaction

IRAK-4 inhibitors. Part III: A series of imidazo[1,2- a]pyridines

Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Efficient parallel synthesis of macrocyclic peptidomimetics

Organic Chemistry / Pharmaceutical Chemistry / Silver / Peptides / Cyclic peptides / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization

4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors

Organic Chemistry / Modeling / Pharmacokinetics / Pharmaceutical Chemistry / Signal Transduction / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase

Structural requirement of arylindolylpropenones as anti-bladder carcinoma cells agents

Organic Chemistry / Flow Cytometry / Cell Cycle / Cell line / Bladder Cancer / Humans / Chalcones / Mode of action / Bioorganic and medicinal Chemistry / Structure activity Relationship / Antineoplastic Agents / Humans / Chalcones / Mode of action / Bioorganic and medicinal Chemistry / Structure activity Relationship / Antineoplastic Agents

8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands

Organic Chemistry / Humans / Structure activity Relationship / Recombinant Proteins / Adenine / Ligands / Molecular Structure / Ligands / Molecular Structure

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