Enzyme Inhibitors - Page 3

DIABLO Promotes Apoptosis by Removing MIHA/XIAP from Processed Caspase 9

Flow Cytometry / Enzyme Inhibitors / Cell Biology / Apoptosis / Western blotting / Biological Sciences / Saccharomyces cerevisiae / Caspases / Cell line / Humans / Uv Radiation / Cell Death / Cytochrome C / Proteins / Caspase / The cell / Transfection / Apoptotic Protease Activating Factor-1 / Mitochondrial Proteins / Biological Sciences / Saccharomyces cerevisiae / Caspases / Cell line / Humans / Uv Radiation / Cell Death / Cytochrome C / Proteins / Caspase / The cell / Transfection / Apoptotic Protease Activating Factor-1 / Mitochondrial Proteins

Download

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

Enzyme Inhibitors / Extracellular Matrix / Pulmonary Hypertension / Signal Transduction / Humans / Anoxia / Reactive Oxygen Species / Mice / Animals / Male / NADPH oxidase / Clinical Sciences / Rats / Time Factors / Transfection / Cell Proliferation / Human Fibroblasts / Pulmonary Artery / Anoxia / Reactive Oxygen Species / Mice / Animals / Male / NADPH oxidase / Clinical Sciences / Rats / Time Factors / Transfection / Cell Proliferation / Human Fibroblasts / Pulmonary Artery

Download

Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene

Flow Cytometry / Immunohistochemistry / Enzyme Inhibitors / DNA damage / Apoptosis / Prevention / Western blotting / DNA / Male Reproduction Health / Toxicity / Reproductive toxicology / Mice / Applied / Animals / Male / Cell Death / Cytoprotection / Red Wine / Lung / tESTIS / Enzyme / Aryl Hydrocarbon Receptor / Apoptose / Public health systems and services research / Stilbenes / Reproductive / Spermatozoa / Somatic Cell Count / Sperm Count / Germ Cell / Applied Toxicology / Prevention / Western blotting / DNA / Male Reproduction Health / Toxicity / Reproductive toxicology / Mice / Applied / Animals / Male / Cell Death / Cytoprotection / Red Wine / Lung / tESTIS / Enzyme / Aryl Hydrocarbon Receptor / Apoptose / Public health systems and services research / Stilbenes / Reproductive / Spermatozoa / Somatic Cell Count / Sperm Count / Germ Cell / Applied Toxicology

Download

Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells

Membrane Proteins / Enzyme Inhibitors / Leukemia / Mitochondria / Molecular Pharmacology / Apoptosis / Caspases / Cell line / Humans / Chronic Lymphocytic Leukemia / Female / Multiple Myeloma / Male / Cell Death / Cytochrome C / Benzodiazepines / Clinical Sciences / Western blot / Heat Shock Proteins / Protein Conformation / B Lymphocytes / Imidazoles / Mitochondrial Membrane Potential / Antineoplastic Agents / Neurosciences / Conformational Change / Apoptosis / Caspases / Cell line / Humans / Chronic Lymphocytic Leukemia / Female / Multiple Myeloma / Male / Cell Death / Cytochrome C / Benzodiazepines / Clinical Sciences / Western blot / Heat Shock Proteins / Protein Conformation / B Lymphocytes / Imidazoles / Mitochondrial Membrane Potential / Antineoplastic Agents / Neurosciences / Conformational Change

Download

In vitro activity of labdane diterpene from Alomia myriadenia (Asteraceae): immunosuppression via induction of apoptosis in monocytes

Electron Microscopy / Flow Cytometry / Enzyme Inhibitors / Apoptosis / Immunopharmacology / Cell Division / DNA / Humans / Natural Product / Asteraceae / Monocytes / Diterpenes / Immunophenotyping / Cell Survival / Propidium Iodide / Cell Division / DNA / Humans / Natural Product / Asteraceae / Monocytes / Diterpenes / Immunophenotyping / Cell Survival / Propidium Iodide

Download

Tissue transglutaminase: a new target to reverse cancer drug resistance

Enzyme Inhibitors / Humans / Animals / Amino Acids / Neoplasms / Antineoplastic Agents / Molecular Targeted Therapy / Transglutaminases / Antineoplastic Agents / Molecular Targeted Therapy / Transglutaminases

Download

The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis

Cellular Biology / Enzyme Inhibitors / Apoptosis / Signal Transduction / Biological Sciences / Cell line / Molecular and cellular biology / Humans / Female / Methionine / Cell line / Molecular and cellular biology / Humans / Female / Methionine

Download

Thermospermine catabolism increases Arabidopsis thaliana resistance to Pseudomonas viridiflava

Plant Biology / Enzyme Inhibitors / Plant diseases / Disease resistance / Pseudomonas / Experimental Botany / Arabidopsis / Putrescine / Spermine / Oxidation-Reduction / Experimental Botany / Arabidopsis / Putrescine / Spermine / Oxidation-Reduction

Download

Novel cell death program leads to neutrophil extracellular traps

Electron Microscopy / Enzyme Inhibitors / Cell Biology / Innate immunity / Apoptosis / Biological Sciences / Antibodies / Humans / Reactive Oxygen Species / Cell Death / Staphylococcus aureus / Catalase / NADPH oxidase / Chromatin / Hydrogen Peroxide / Neutrophils / Nuclear envelope / Phagocytosis / Experimental Medicine / The cell / Cell Survival / Vacuoles / Biological Sciences / Antibodies / Humans / Reactive Oxygen Species / Cell Death / Staphylococcus aureus / Catalase / NADPH oxidase / Chromatin / Hydrogen Peroxide / Neutrophils / Nuclear envelope / Phagocytosis / Experimental Medicine / The cell / Cell Survival / Vacuoles

Download

Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release

Virology / Calcium / Membrane Proteins / Enzyme Inhibitors / Apoptosis / Biological Sciences / Humans / Endoplasmic Reticulum / P-glycoprotein / Calcium Homeostasis / Homeostasis / Transfection / Tumor Necrosis Factor–α (TNF) / Arachidonic Acid / Biological Sciences / Humans / Endoplasmic Reticulum / P-glycoprotein / Calcium Homeostasis / Homeostasis / Transfection / Tumor Necrosis Factor–α (TNF) / Arachidonic Acid

Download

Yeast d-Amino Acid Oxidase: Structural Basis of its Catalytic Properties

Molecular Biology / Kinetics / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Molecular / Crystal structure / Enzyme / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Yeasts / D structure / Glutathione Reductase / Catalytic Activity / Biochemistry and cell biology / Dimerization / Crystal structure / Enzyme / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Yeasts / D structure / Glutathione Reductase / Catalytic Activity / Biochemistry and cell biology / Dimerization

Download

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Organic Chemistry / Kinetics / Modeling / Crystallization / Enzyme Inhibitors / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase

Download

Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Organic Chemistry / Cytokines / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents

Download

A novel NADPH:diamide oxidoreductase activity in Arabidopsis thaliana P1 ζ-crystallin

Enzyme Inhibitors / Oxidative Stress / Arabidopsis thaliana / Escherichia coli / Animals / Oxidoreductases / Arabidopsis / European / Substrate Specificity / Amino Acid Sequence / Recombinant Proteins / Crystallins / Hydrogen-Ion Concentration / PLANT PROTEINS / Nucleotides / Biochemistry and cell biology / Nitrofurantoin / Dimerization / Oxidoreductases / Arabidopsis / European / Substrate Specificity / Amino Acid Sequence / Recombinant Proteins / Crystallins / Hydrogen-Ion Concentration / PLANT PROTEINS / Nucleotides / Biochemistry and cell biology / Nitrofurantoin / Dimerization

Download

Rho GTPase Cdc42 is essential for human T-cell development

Hematology / Flow Cytometry / Enzyme Inhibitors / Stem Cell / Gene expression / Western blotting / Signal Transduction / Humans / Child / T cell development / Cell Polarity / T lymphocytes / Cell Proliferation / Rho GTPase / Western blotting / Signal Transduction / Humans / Child / T cell development / Cell Polarity / T lymphocytes / Cell Proliferation / Rho GTPase

Download

Arylfurans as potential Trypanosoma cruzi trypanothione reductase inhibitors

Medical Microbiology / Enzyme Inhibitors / Mice / Animals / Male / Chagas disease / Total Synthesis / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Furans / Chagas disease / Total Synthesis / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Furans

Download