Enzyme Inhibitors

Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum

Organic Chemistry / Enzyme Inhibitors / Bacteria / Enzyme / High Resolution / Spectrum analysis / Polygonum Cuspidatum / Bioorganic and medicinal Chemistry / DNA primase / Spectrum analysis / Polygonum Cuspidatum / Bioorganic and medicinal Chemistry / DNA primase

Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Organic Chemistry / Enzyme Inhibitors / High throughput screening / Iterative Design / Enzyme / Acetic Acid / Structure activity Relationship / RNA Dependent RNA Polymerase / Acetic Acid / Structure activity Relationship / RNA Dependent RNA Polymerase

Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors

Organic Chemistry / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / Fourier transform infrared spectroscopy / Oral Hypoglycemic Agents / Bioorganic and medicinal Chemistry / Imidazoles / Structure activity Relationship / Molecular Structure / Acarbose / Bioorganic and medicinal Chemistry / Imidazoles / Structure activity Relationship / Molecular Structure / Acarbose

Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology

Adaptive Increase of Amino Acid Transport System A Requires ERK1/2 Activation

Enzyme Inhibitors / Biological Chemistry / Flavonoids / Biological Sciences / Humans / Biological / Proline / Phosphorylation / Mitogen Activated Protein Kinase / CHEMICAL SCIENCES / Amino Acids / Human Fibroblasts / Culture Media / Sirolimus / Cell Size / Biological / Proline / Phosphorylation / Mitogen Activated Protein Kinase / CHEMICAL SCIENCES / Amino Acids / Human Fibroblasts / Culture Media / Sirolimus / Cell Size

Establishment of a Cell-Free System of Neuronal Apoptosis: Comparison of Premitochondrial, Mitochondrial, and Postmitochondrial Phases

Enzyme Inhibitors / Mitochondria / Apoptosis / Neuronal cell death / Caspases / Cerebellum / Animals / Cytochrome C / Peptides / The / Neurons / Caspase / Tamoxifen / Rats / Cysteine endopeptidases / Nervous System / Cell free System / Staurosporine / Adenosine Triphosphate / DNA fragmentation / Cerebellum / Animals / Cytochrome C / Peptides / The / Neurons / Caspase / Tamoxifen / Rats / Cysteine endopeptidases / Nervous System / Cell free System / Staurosporine / Adenosine Triphosphate / DNA fragmentation

Novel copper amine oxidase activity from rat liver mitochondria matrix

Biochemistry / Biophysics / Enzyme Inhibitors / Transmission Electron Microscopy / Enzyme Kinetics / Dopamine / Copper / Animals / Enzyme Inhibition / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Affinity chromatography / Enzyme / Hydrogen Peroxide / Rats / Substrate Specificity / Enzyme activity / Enzymatic Activity / Biochemistry and cell biology / Dopamine / Copper / Animals / Enzyme Inhibition / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Affinity chromatography / Enzyme / Hydrogen Peroxide / Rats / Substrate Specificity / Enzyme activity / Enzymatic Activity / Biochemistry and cell biology

Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway

Enzyme Inhibitors / Prefrontal Cortex / Signal Transduction / Animals / Male / Rats / Endocannabinoids / Pyrazoles / Action Potentials / Carbamates / Benzamides / Piperidines / Rats / Endocannabinoids / Pyrazoles / Action Potentials / Carbamates / Benzamides / Piperidines

5′-AMINOIMIDAZOLE-4-CARBOXAMIDE Riboside Induces Apoptosis in Human Neuroblastoma Cells

Neuroscience / Psychology / Enzyme Inhibitors / Apoptosis / Caspases / Cell line / Cell Differentiation / Brain / Humans / Acetylcholine / Neurons / Differentiation / Enzyme / Norepinephrine / Caspase / Neuroblastoma / PBS / Retinoic Acid / Tretinoin / Protein Kinase / Bovine Serum Albumin / Neurosciences / Phorbol ester / Serum albumin / Cell line / Cell Differentiation / Brain / Humans / Acetylcholine / Neurons / Differentiation / Enzyme / Norepinephrine / Caspase / Neuroblastoma / PBS / Retinoic Acid / Tretinoin / Protein Kinase / Bovine Serum Albumin / Neurosciences / Phorbol ester / Serum albumin

Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists

Influenza virus neuraminidase inhibitors

Treatment Outcome / Enzyme Inhibitors / Influenza virus / Humans / Oseltamivir / Neuraminidase / Lancet / Guanidines / Antiviral Agents / Sialic Acids / Acetamides / Zanamivir / Neuraminidase / Lancet / Guanidines / Antiviral Agents / Sialic Acids / Acetamides / Zanamivir

Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

Organic Chemistry / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / Nitric Oxide Synthase / Thalidomide

Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

Enzyme Inhibitors / Mycobacterium tuberculosis

Synthetic UDP-Furanoses as Potent Inhibitors of Mycobacterial Galactan Biogenesis

Organic Chemistry / Enzyme Inhibitors / Chemistry Biology / Recombinant Proteins / Biochemistry and cell biology / Klebsiella pneumoniae

Protein Kinase C Signaling Transduces Endorphin-Primed Cardiogenesis in GTR1 Embryonic Stem Cells

Stem Cells / Human Embryonic Stem Cells / Enzyme Inhibitors / Gene expression / Molecular Mechanics / Signal Transduction / Cell line / Cell Differentiation / Animals / Embryonic Stem Cell / Heart / Transcription Factor / Dynorphins / Enzyme / Clinical Sciences / Cell nucleus / Isoenzymes / Circulation / Opioid Receptor / Cell Surface Markers / Endorphins / ES cell / Signal Transduction / Cell line / Cell Differentiation / Animals / Embryonic Stem Cell / Heart / Transcription Factor / Dynorphins / Enzyme / Clinical Sciences / Cell nucleus / Isoenzymes / Circulation / Opioid Receptor / Cell Surface Markers / Endorphins / ES cell

NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms

Drug interactions / Enzyme Inhibitors / Neurophysiology / Patch-clamp and imaging techniques / Hippocampus / Mice / Animals / Synaptic Transmission / Time Factors / Imidazoles / Gamma-Aminobutyric Acid / Calcium Channel Blockers / Mice / Animals / Synaptic Transmission / Time Factors / Imidazoles / Gamma-Aminobutyric Acid / Calcium Channel Blockers

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