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Enzyme Inhibitors
Enzyme Inhibitors
Novel IKK inhibitors: beta-carbolines
Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship
Novel IKK inhibitors: beta-carbolines
Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship
Autocrine VEGF-A/KDR loop protects epithelial ovarian carcinoma cells from anoikis
Cancer / Enzyme Inhibitors / Western blotting / Humans / Female / Immunoprecipitation / Fluorescent Antibody Technique / Epithelial cells / Enzyme Linked Immunosorbent Assay / Vascular endothelial growth factor receptor / Immunoprecipitation / Fluorescent Antibody Technique / Epithelial cells / Enzyme Linked Immunosorbent Assay / Vascular endothelial growth factor receptor
Novel IKK inhibitors: beta-carbolines
Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship
Spirocyclopropyl pyrrolidines as a new series of α-l-fucosidase inhibitors
Organic Chemistry / Titanium / Enzyme Inhibitors / Kidney / Animals / Cattle / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Cattle / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship
AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats
Obesity / Enzyme Inhibitors / Protein Kinases / Blood Glucose / Animals / Rats / Protein Kinase Inhibitors / Biochemistry and cell biology / Rats / Protein Kinase Inhibitors / Biochemistry and cell biology
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase
Organic Chemistry / Enzyme Inhibitors / Humans / Mice / Blood Pressure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure
Semicarbazide-Sensitive Amine Oxidases: Enzymes with Quite a Lot to Do
Neurology / Toxicology / Enzyme Inhibitors / Neurotoxicology / Humans / Animals / TNF / Enzyme / Potential Function / Xenobiotics / Substrate Specificity / Xenobiotic / Neurosciences / Semicarbazide / Amine / Animals / TNF / Enzyme / Potential Function / Xenobiotics / Substrate Specificity / Xenobiotic / Neurosciences / Semicarbazide / Amine
NADPH Oxidase Plays a Central Role in Blood-Brain Barrier Damage in Experimental Stroke
Enzyme Inhibitors / Clostridium difficile / Stroke / Endothelial Cells / Reactive Oxygen Species / Mice / Blood brain barrier / Animals / Male / Electrical Resistance / Actin Cytoskeleton / Brain injury / Mitogen Activated Protein Kinase / NADPH oxidase / Clinical Sciences / Endothelial cell / Cerebral Ischemia / Rho-kinase / Reperfusion injury / Sus Scrofa / Ischemia–reperfusion / Neurosciences / Brain Edema / Middle Cerebral Artery / Protein Transport / Mice / Blood brain barrier / Animals / Male / Electrical Resistance / Actin Cytoskeleton / Brain injury / Mitogen Activated Protein Kinase / NADPH oxidase / Clinical Sciences / Endothelial cell / Cerebral Ischemia / Rho-kinase / Reperfusion injury / Sus Scrofa / Ischemia–reperfusion / Neurosciences / Brain Edema / Middle Cerebral Artery / Protein Transport
Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria
Free Radicals / Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / PT / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / CSA / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists / Dopamine / Cell Differentiation / Animals / Male / Cell Death / PT / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / CSA / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
PACAP-38 Protects Cerebellar Granule Cells from Apoptosis
Enzyme Inhibitors / Flavonoids / Apoptosis / Multidisciplinary / Neuropeptides / Cerebellum / Protein Kinases / Animals / Potassium / Neurons / Rats / Necrosis / Neuroprotective Agents / DNA fragmentation / Cerebellum / Protein Kinases / Animals / Potassium / Neurons / Rats / Necrosis / Neuroprotective Agents / DNA fragmentation
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder
Stress / Neuropsychopharmacology / Electroencephalography / Enzyme Inhibitors / Post traumatic stress disorder / Cortisol / Humans / Male / Veterans / Sleep / Electromyography / Polysomnography / Middle Aged / Repeated Measures / Adult / Adrenocorticotropic Hormone / Rem Sleep / Indexation / Biological activity / Delta Rhythm / Case Control Studies / Corticotropin-releasing factor / Cortisol / Humans / Male / Veterans / Sleep / Electromyography / Polysomnography / Middle Aged / Repeated Measures / Adult / Adrenocorticotropic Hormone / Rem Sleep / Indexation / Biological activity / Delta Rhythm / Case Control Studies / Corticotropin-releasing factor
The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1
Enzyme Inhibitors / Signal Transduction / Biological Sciences / Mitosis / Protein Kinases / Mutation / Phosphorylation / Schizosaccharomyces Pombe / Time Factors / Size / Cytokinesis / Protein Kinase / Cell Cycle Proteins / Mutation / Phosphorylation / Schizosaccharomyces Pombe / Time Factors / Size / Cytokinesis / Protein Kinase / Cell Cycle Proteins
Kojic acid–tripeptide amide as a new tyrosinase inhibitor
Peptide Science / Enzyme Inhibitors / Stability / Biological Sciences / Biopolymers / Kojic Acid / CHEMICAL SCIENCES / Structure activity Relationship / Drug Stability / Molecular Structure / Kojic Acid / CHEMICAL SCIENCES / Structure activity Relationship / Drug Stability / Molecular Structure
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